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2021 GMC Sierra 2500 problems: engine and transmission complaints and recalls

HIGH COMPLAINT SIGNAL
48%
19 of 40 relevant owner complaints are about the engine, transmission or fuel system

48% of relevant owner complaints filed with NHTSA on the 2021 GMC Sierra 2500 are about the engine, transmission or fuel system. That is a model-level pattern, not bad luck.

Worse than 60% of the 1,789 model years we track (2010–2023).

Excludes 11 airbag, lighting and seat-belt recall complaints that would otherwise mask the signal (unadjusted: 37%).

NHTSA data checked October 3, 2026
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Does the 2021 GMC Sierra 2500 have transmission problems?

Owner complaints say yes, as a model-year pattern. 19 of 40 relevant complaints filed with NHTSA about the 2021 GMC Sierra 2500 concern the engine, transmission or fuel system (48%), and the largest group is filed under power train (12). For comparison, the 2020 scores 47% and the 2022 scores 30%. On a test drive, check for shuddering, slipping, delayed or harsh shifts, or a whine at speed. This describes the model year, not any one car: a well-maintained or already-repaired example can be fine, and a clean model year can still have a bad car in it.

Drivetrain complaints
19
engine, transmission, fuel
Total complaints
51
this model year
Fires reported
1
owner-reported
Recall campaigns
6
4 crashes · 1 injuries

Complaints by component

POWER TRAIN12 · 24%
EXTERIOR LIGHTING9 · 18%
ENGINE8 · 16%
SERVICE BRAKES6 · 12%
ELECTRICAL SYSTEM6 · 12%
STRUCTURE5 · 10%

The years either side

2010
11%
5 of 59
2011
33%
25 of 106
2012
38%
18 of 60
2013
34%
24 of 85
2014
40%
23 of 131
2015
38%
31 of 147
2016
28%
16 of 65
2017
46%
41 of 98
2018
40%
12 of 35
2019
38%
11 of 32
2020
47%
35 of 76
2021
48%
19 of 51
2022
30%
12 of 43
2023
66%
21 of 32

Manufacturers fix things mid-generation. A bad year next to a clean one is common; the fix usually arrived in between.

Cleaner alternatives

Same car, a better year

Other heavy-duty pickups with no elevated signal

The percentage is each model year's drivetrain complaint share. No elevated signal describes the model year, not any one car; a well-kept example of a flagged model can still be the right buy, and any of these still needs an inspection.

What owners reported

POWER TRAIN10/29/2025CRASH1 INJURED
The contact owns a 2021 GMC Sierra 2500. The contact stated that while driving at 50 MPH, the contact was pulling a trailer that he had loaded, and he drove around a curve, the gear shifted down independently, and the trailer pushed the vehicle off the right side, causing him to crash into a post and embankment. The co…
FUEL/PROPULSION SYSTEM07/30/2026
After finishing a long drive south, I shut the engine off and a yellow engine code popped on. I connected my computer to it and revealed a P129F code (fuel pump control module). I have noticed that other GMC models have been included in a recall concerning this problem. The 2021 GMC 2500 Denali should be also since …
POWER TRAIN,ENGINE,FUEL/PROPULSION SYSTEM06/26/2026
I am reporting repeated failures involving both the transmission and diesel emissions (DEF) system on my 2021 GMC Sierra 2500HD Denali equipped with the 6.6L Duramax diesel engine and Allison 10-speed automatic transmission. While under warranty, the truck required replacement of the aftertreatment fuel injector and l…

Three of 19 drivetrain complaints. The full report shows more, with quotes about the engine in the car you are looking at first.

Recall campaigns on the 2021 GMC Sierra 2500 (6)

TIRES:TEMPORARY/EMERGENCY SPARE TIRE
General Motors, LLC. (GM) is recalling certain 2020-2021 Chevrolet Silverado 2500 and GMC Sierra 2500 vehicles equipped with a 17" spare tire (RPO ZHQ or ZXT) and either …
SERVICE BRAKES, HYDRAULIC:POWER ASSIST:ELECTRIC:CONTROL MODULE
General Motors, LLC (GM) is recalling certain 2021-2022 Chevrolet Silverado 2500, Silverado 3500, GMC Sierra 2500, and Sierra 3500 vehicles with electronic brake control …
SEAT BELTS
General Motors, LLC (GM) is recalling certain 2019-2021 Chevrolet Silverado 1500 and GMC Sierra 1500, 2021 Chevrolet Suburban and Tahoe and GMC Yukon XL and 2020-2021 Che…

This does not say whether a particular car has an open, unrepaired recall. That depends on the VIN.

Before you buy a 2021 GMC Sierra 2500

Questions people ask about the 2021 GMC Sierra 2500

Does the 2021 GMC Sierra 2500 have transmission problems?

Owner complaints say yes, as a model-year pattern. 19 of 40 relevant complaints filed with NHTSA about the 2021 GMC Sierra 2500 concern the engine, transmission or fuel system (48%). Before buying one, have an independent mechanic check the transmission and ask the seller whether it has been repaired or replaced.

Are there engine or transmission recalls on the 2021 GMC Sierra 2500?

NHTSA lists 6 recall campaigns on the 2021 GMC Sierra 2500. Whether a specific car still has one open depends on its VIN.

Which GMC Sierra 2500 years are better?

Among the GMC Sierra 2500 years we track, the 2010 (11%), the 2016 (28%) and the 2022 (30%) have a lower engine and transmission complaint share than the 2021 (48%). Manufacturers fix things mid-generation, so the year before or after can be a different car.

Should I buy a 2021 GMC Sierra 2500?

That depends on the car in front of you, not just the model year. The 2021 GMC Sierra 2500 has an elevated transmission complaint pattern, so treat it as a car that needs proof: service records showing transmission work, a cold-start test drive, and an independent pre-purchase inspection focused on the transmission. A well-kept or already-repaired example can be a fine car; an unknown one is a gamble.

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Experimental model-level information. This is not a vehicle inspection, vehicle-history report, financial advice or purchase recommendation. It describes patterns across a model year, not the condition of any individual vehicle.